Progressive Multiple Sclerosis by Alastair Wilkins

Author:Alastair Wilkins
Language: eng
Format: epub
Publisher: Springer International Publishing, Cham

Dantrolene

Ryanodine receptor-mediated reduction of calcium release from sarcoplasmic reticulum

Sedation, weakness, gastrointestinal upset and hepatotoxicity (necessitating monitoring of liver function)

Gabapentin

GABA analogue but also binds to α2-δ subunit protein of voltage-gated calcium channels with consequent reduction in release of excitatory neurotransmitters

Drowsiness, sedation, gastrointestinal upset, dizziness

Pregabalin

Increased GABA activity and reduction in excitatory neurotransmission via voltage-gated calcium channels

Somnolence, gastrointestinal upset, mood disturbance

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